3D FEM Model of a Human Cochlea and a Cochlear Implant
- 3D finite element method (FEM) models of human cochleae to simulate the voltage distribution in the cochlea when stimulating with a cochlear implant (CI)
- The 3D model can be customized based on landmarks from CBCT imaging data to represent individual patients
- Voltage distributions can be used to study the activation of the auditory nerve by a CI
3D FEM Model of Auditory Nerve and Auditory Nerve Implant
- 3D FEM model of a human cochlea and auditory nerve to predict the voltage spread with the novel auditory nerve implant (ANI)
- The ANI delivers intraneural stimulation to the auditory nerve through penetrating electrodes
Auditory Nerve Fiber models
- Phenomenological and physiological models of auditory nerve fibers stimulated acoustically, electrically, or with electric-acoustic stimulation (EAS)
- Neuron models can be coupled to FEM models for realistic current input
Electrophysiology and Neural Health
- Models of neural degeneration to study the effect on thresholds, evoked potentials, or signal transmission
- A model of the acoustically or electrically evoked compound action potential (aCAP/eCAP) measured through intracochlear electrodes
Auditory Experiments Simulations
- Computational models to simulate performance of cochlea implant users in different auditory experiments
- Objective measurements of speech intelligibility from neural spike activity
- Daniel Kipping
- Franklin Alvarez
- Yixuan Zhang (B.Sc.)
- Nogueira et al., 2016. Validation of a Cochlear Implant Patient-Specific Model of the Voltage Distribution in a Clinical Setting. Front. Bioeng. Biotechnol. 4, 1–16.
- Jürgens et al., 2018. The effects of electrical field spatial spread and some cognitive factors on speech-in-noise performance of individual cochlear implant users - A computer model study. PLoS One 13, e0193842.
- Ashida and Nogueira, 2018. Spike-Conducting Integrate-and-Fire Model. eneuro 5, ENEURO.0112-18.2018.
- Kipping and Nogueira, 2022. A computational model of a single auditory nerve fiber for electric-acoustic stimulation. J. Assoc. Res. Otolaryngol. 23, 835-858. Source code: Zenodo or GitHub.
- Alvarez et al., 2022. A Computational Model to Simulate Spectral Modulation and Speech Perception Experiments of Cochlear Implant Users. Frontiers in Neuroinformatics (under review).