2024
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Chunjiang Wei, Ziwen Gao, Robert Mau, Thomas Eickner, Gabor Jüttner, Nicklas Fiedler, Hermann Seitz, Thomas Lenarz, Verena Scheper Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model Pharmaceutics, September 2024, 16(9), 1236
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Anning Chen,Jiaxi Qu,Yunyou You, Jing Pan,Verena Scheper, Yongdong Lin, Xuexin Tian, Fan Shu, Yanjing Luo, Jie Tang, Hongzheng Zhang Intratympanic injection of MSC-derived small extracellular vesicles protects spiral ganglion neurons from degeneration Biomedicine & Pharmacotherapy, September 2024; Vol. 179, 117392
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Chunjiang Wei, Ziwen Gao, Martina Knabel, Martin Ulbricht, Stefan Senekowitsch, Peter Erfurt,Norman Maggi, Bastian Zwick, Thomas Eickner, Farnaz Matin-Mann, Anne Seidlitz, Thomas Lenarz, Verena Scheper Development of a drug delivering round window niche implant for cochlear pharmacotherapy Drug Delivery, August 2024, VOL. 31, NO. 1, 2392755
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Angrisani N, von der Ahe C, Willumeit-Römer R, Windhagen H, Scheper V, Schwarze M, Wiese B, Helmholz H, Reifenrath J Treatment of osteoarthritis by implantation of Mg- and WE43-cylinders - a preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits Bioactive Materials, October 2024, 366-377
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Carles L, Gibaja A, Scheper V, Alvarado JC, Almodovar C, Lenarz T, Juiz JM Efficacy and Mechanisms of Antioxidant Compounds and Combinations Thereof against Cisplatin-Induced Hearing Loss in a Rat Model Antioxidants, June 2024, 13(7), 761;
2023
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Grzybowski M, Malfeld K, Lenarz T, Scheper V, Schurzig D Optimization of pharmacological interventions in the guinea pig animal model—a new approach to calculate the perilymph volume of the scala tympani Front. Neurosci., Sec. Translational Neuroscience, December 2023
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Wersényi G, Scheper V, Spagnol S, Eixelberger T, Wittenberg T Cost-effective 3D scanning and printing technologies for outer ear reconstruction: current status Head Face Med 19, 46, October 2023
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Schwieger J, Scheper V, Lenarz T, Vogt PM, Strauß S. Auditory Neurons on the Silk Road – spider silk for bridging the nerve-electrode-gap Current Directions in Biomedical Engineering 2023;9(1): 246-249, September 2023
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Knabel M, Dräger G, Lenarz T, Scheper V. Development and validation of a 3D-printed artificial round window niche for use in release kinetics analysis of round window niche implants Transactions on Additive Manufacturing Meets Medicine, Trans. AMMM, Vol. 5 No. 1, September 2023
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Schwieger J, Gao Z, Lenarz T, Munro G, Petersen KA, Scheper V. "Of Mice and Men": the relevance of Cometin and Erythropoietin origin for its effects on murine spiral ganglion neuron survival and neurite outgrowth in vitro Front. Neurosci., August 2023
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Mau R, Eickner T, Jüttner G, Gao Z, Wei C, Fiedler N, Senz V, Lenarz T, Grabow N, Scheper V, Seitz H. Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds Pharmaceutics Mai 2023
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Behrends W, Ahrens D, Bankstahl J, Esser KH, Paasche G, Lenarz T, Scheper V. Refinement of systemic guinea pig deafening in hearing research: Sensorineural hearing loss induced by co-administration of kanamycin and furosemide via the leg veins Laboratory Animals, April 2023
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Domsta V, Hänsch Ch, Lenz S, Gao Z, Matin-Mann F, Scheper V, Lenarz T, Seidlitz A. The Influence of Shape Parameters on Unidirectional Drug Release from 3D Printed Implants and Prediction of Release from Implants with Individualized Shapes Pharmaceutics, April 2023
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Behrends W, Wolf K, Raggl S, Fröhlich M, Eicjner T, Dohr D, Esser KH, Lenarz T, Scheper V, Paasche G. Dual Drug Delivery in Cochlear Implants: In Vivo Study of Dexamethasone Combined with Diclofenac or Immunophilin Inhibitor MM284 in Guinea Pigs Pharmaceutics, February 2023
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Matin-Mann F, Gao Z, Wei C, Repp F, Artukarslan E, John S, Alcacer Labrador D, Lenarz T, Scheper V. Development and In-Silico and Ex-Vivo Validation of a Software for a Semi-Automated Segmentation of the Round Window Niche to Design a Patient Specific Implant to Treat Inner Ear Disorders J. Imaging, February 2023
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Juiz JM, Fuentes Santamaria V, Scheper V, Lenarz T. Editorial: Deafness, aging and Alzheimer's disease: Neurobiological links and therapy optionsFront. Neurosci., January 2023
2022
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Malfeld K, Armbrecht N, Pich A, Volk HA, Lenarz T, Scheper V. Prevention of Noise-Induced Hearing Loss In Vivo: Continuous Application of Insulin-like Growth Factor 1 and Its Effect on Inner Ear Synapses, Auditory Function and Perilymph Proteins Int. J. Molecular Sciences, December 2022.
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Förster C Y, Shityakov S, Scheper V, Lenarz T Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and Alzheimer’s Disease—Are Systemic Approaches for Diagnosis and Therapy Required? Biomolecules, November 2022
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Johne M, Helgers S O A, Alam M , Jelinek J, Hubka P, Krauss J K, Scheper V, Kral A, Schwabe K Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model Front. Neurosci. Sec. Neurodegeneration, November 2022
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Malfeld K, Baumhoff P, Volk HA, Lenarz T, Scheper V. Local Long-Term Inner Ear Drug Delivery in Normal Hearing Guinea Pig—An Animal Model to Develop Preventive Treatment for Noise-Induced Hearing Loss Biomolecules, October 2022.
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Mau R, Schick P, Matin-Mann F, Gao Z, Alcacer Labrador D, John S, Repp F, Lenarz T, Weitschies W, Scheper V, Seidlitz A, Seitz H. Digital light processing and drug stability of Dexamethasone-loaded implant prototypes for medical treatment of the inner ear Transactions on Additive Manufacturing Meets Medicine, September 2022
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Gibaja A, Alvarado JC, Scheper V, Carles J, Juiz JM. Kanamycin and Cisplatin Ototoxicity: Differences in Patterns of Oxidative Stress, Antioxidant Enzyme Expression and Hair Cell Loss in the Cochlea Antioxidants, September 2022
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Mau R, Nazir J, Gao Z, Alcacer Labrador D, Repp F, John S, Lenarz T, Scheper V, Seitz H, Matin-Mann F. Digital Light Processing of Round Window Niche Implant Prototypes for Implantation Studies Current Directions in Biomedical Engineering, September 2022
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Matin-Mann F, Gao Z, Schwieger J, Ulbricht M, Domsta V, Senekowitsch S, Weitschies W, Seidlitz A, Doll K, Stiesch M, Lenarz T, Scheper V. Individualized, Additively Manufactured Drug-Releasing External Ear Canal Implant for Prevention of Postoperative Restenosis: Development, In Vitro Testing, and Proof of Concept in an Individual Curative Trial Pharmaceutics, June 2022
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Schwieger J, Frisch A, Rau TS, Lenarz T, Hügl S, Scheper V. 3D Printed Cell Culture Chamber for Testing the Effect of Pump-Based Chronic Drug Delivery on Inner Ear Tissue Biomolecules, April 2022
2021
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Gao Z, Schwieger J, Matin-Mann F, Behrens P, Lenarz T, Scheper V. Dexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro Biomolecules, December 2021
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Gao Z, Matin-Mann F, Wei C, Lenarz T, Weber C, John S, Scheper V. 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study Current Directions in Biomedical Engineering, December 2021
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Abdoul T, Schwieger J, Lenarz T, Nogueira W, Scheper V. Investigation of auditory neuronal survival and outgrowth using a cochlear implant in an artificial cochlear model Current Directions in Biomedical Engineering, December 2021
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Peck CT, Schwieger J, Lenarz T, Scheper V. Stability and Biocompatibility Tests of Alginate as Cochlear Implant Coating Material Current Directions in Biomedical Engineering, December 2021
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Mau R, Jüttner G, Gao Z, Matin F, Alcacer Labrador D, Repp F, John S, Scheper V, Lenarz T, Seitz H. Micro injection molding of individualised implants using 3D printed molds manufactured via digital light processing Current Directions in Biomedical Engineering, December 2021
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Usevitch DE, Park A, Scheper V, Abbott JJ. Estimating the Pose of a Guinea-pig Cochlea Without Medical Imaging Otology & Neurotology, October 2021
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Angrisani N, Willumeit-Römer R, Windhagen H, Mavila Chathoth B, Scheper V, Wiese B, Helmholz H, Reifenrath J. Small-sized magnesium cylinders influence subchondral bone quality in osteoarthritic rabbits - an in vivo pilot study European Cells & Materials 42:179-195, September 2021
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Matin F, Gao Z, Bronzlik P, Lenarz T, Scheper V. A 3D printed patient specific artificial outer ear model for use in auricle reconstruction surgery: a clinical feasibility study Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021);
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Mau R, Jüttner G, Gao Z, Matin F, Alcacer Labrador D, Repp F, John S, Scheper V, Lenarz T, Seitz H. Rapid tooling for micro injection molding of micro medical devices via digital light processing Transactions on Additive Manufacturing Meets Medicine, Vol 3 No 1 (2021)
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Shityakov S, Hayashi K, Störk S, Scheper V, Lenarz T, Förster CY The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy? Biomolecules, 2021; 11(6):900
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Matin F, Gao Z, Repp F, John S, Lenarz T, Scheper V. Determination of the Round Window Niche Anatomy Using Cone Beam Computed Tomography Imaging as Preparatory Work for Individualized Drug-Releasing Implants Journal of Imaging, 2021 April 23.
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Schurzig D, Fröhlich M, Raggl S, Scheper V, Lenarz T, Rau TS. Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear Life, 2021 April 21.
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Malfeld K, Armbrecht N, Volk HA, Lenarz T, Scheper V. In Situ 3D-Imaging of the Inner Ear Synapses with a Cochlear Implant Life, 2021 April 01.
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Gärtner L, Klötzer K, Lenarz T, Scheper V. Correlation of Electrically Evoked Compound Action Potential Amplitude Growth Function Slope and Anamnestic Parameters in Cochlear Implant Patients—Identification of Predictors for the Neuronal Health Status Life, 2021 March 05.
2020
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Gao Z, Matin F, Weber C, John S, Lenarz T, Scheper V. High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis Life (Basel), 2020 Dec 17.
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Nagai M, Scheper V, Lenarz T, Förster CY. The insular cortex as a vestibular area in relation to autonomic function Clin Auton Res. 2020 Dec 1.
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Knipper M, van Dijk P,Schulze H, Mazurek B, Krauss P, Scheper V, Warnecke A, Schlee W, Schwabe K, Singer W, Braun C, Delano PH, Fallgatter AJ, Ehlis A, Searchfield GD, Munk MHJ, Baguley DM, Rüttiger L. The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants J. Neurosci. Res., 2020 September 16.
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Scheper V, Seidel-Effenberg I, Lenarz T, Stöver T, Paasche G. Consecutive Treatment with Brain-Derived Neurotrophic Factor and Electrical Stimulation Has a Protective Effect on Primary Auditory Neurons. Brain Sci.2020, August 15.
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Scheper V, Schmidtheisler M, Lasch F, von der Leyen H, Koch A, Schwieger J, Büchner A, Lesinski-Schiedat A, Lenarz T. Randomized placebo-controlled clinical trial investigating the effect of antioxidants and a vasodilator on overall safety and residual hearing preservation in cochlear implant patients . Trials, 2020 July 15.
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Schwieger J, Hamm A, Gepp M M, Schulz A, Hoffmann A, Lenarz T, Scheper V Alginate-encapsulated brain-derived neurotrophic factor–overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons . J. Tissue Eng. 11, 2020 April 17.
2019
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Förster CY, Scheper V, Lenarz T. Hearing loss and strial microvascular pathology-towards unravelling the functional contribution of the blood-labyrinth barrier. Otorhinolaryngol Head Neck Surg., 2019 November 25.
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Yilmaz-Bayraktar S, Schwieger J, Scheper V, Lenarz T, Böer U, Kreienmeyer M, Torrente M, Doll T. Decellularized equine carotid artery layers as matrix for regenerated neurites of spiral ganglion neurons. Int. J. Art. Organs, 2019 August 22.
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Scheper V, Schwieger J, Hamm A, Lenarz T, Hoffmann A. BDNF-overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro. J. Neurosci. Res., 2019 June 30.
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Scheper V, Hoffmann A, Gepp M M, Schulz A, Hamm A, Pannier C, Hubka P, Lenarz T, Schwieger J. Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation. Front. Cell. Neurosci., 2019 May 14.
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Hügl S, Scheper V, Gepp M M, Lenarz Th, Rau Th S, Schwieger J. Coating stability and insertion forces of an alginate-cell-based drug delivery implant system for the inner ear. J Mech Behav Biomed Mater. doi: 10.1016/j.jmbbm.2019.05.007. Epub 2019 May 4.
2017
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Berger C, Kühne D, Scheper V, Kral A. Congenital deafness affects deep layers in primary and secondary auditory cortex. J Comp Neurol. 2017 Oct 1;525(14):3110-3125. doi: 10.1002/cne.24267. Epub 2017 Jul 13.
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Scheper V, Hessler R, Hütten M, Wilk M, Jolly C, Lenarz T, Paasche G. Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation.PLoS One. 2017 Aug 31;12(8):e0183820. doi: 10.1371/journal.pone.0183820. eCollection 2017
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Konerding WS, Janssen H, Hubka P, Tornøe J, Mistrik P, Wahlberg L, Lenarz T, Kral A, Scheper V. Encapsulated cell device approach for combined electrical stimulation and neurotrophic treatment of the deaf cochlea. Hear Res. 2017 Apr 25;350:110-121.
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Schmitt HA, Pich A, Schröder A, Scheper V, Lilli G, Reuter G, Lenarz T. Proteome Analysis of Human Perilymph Using an Intraoperative Sampling Method. J Proteome Res. 2017 Apr 13. doi: 10.1021/acs.jproteome.6b00986.
2016
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Scheper V, Leifholz M, von der Leyen H, Keller M, Denkena U, Koch A, Karch A, Miller J, Lenarz T. ACEMg-mediated hearing preservation in cochlear implant patients receiving different electrode lengths (PROHEARING): study protocol for a randomized controlled trial. Trials. 2016 Aug 8;17:394. doi: 10.1186/s13063-016-1526-7
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Schwieger J, Esser KH, Lenarz T, Scheper V. Establishment of a long-term spiral ganglion neuron culture with reduced glial cell number: Effects of AraC on cell composition and neurons. J Neurosci Methods. 2016 Aug 1;268:106-16. doi: 10.1016/j.jneumeth.2016.05.001. Epub 2016 May 3.
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Wilk M, Hessler R, Mugridge K, Jolly C, Fehr M, Lenarz T, Scheper V. Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode. PLoS One. 2016 Feb 3;11(2):e0147552. doi: 10.1371/journal.pone.0147552.
2015
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Schwieger J, Warnecke A, Lenarz T, Esser KH, Scheper V. Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination. PLoS One. 2015 Aug 11;10(8):e0133680. doi: 10.1371/journal.pone.0133680.
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Lenarz T, Scheper V. Preserving Residual Hearing in Cochlear Implant Patients. in "Free Radicals in ENT Pathology". Eds.: Miller J, LePrell CG, Rybak L, Springer 2015, ISBN 978-3-319-13473-4
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Linke I, Fadeeva E, Scheper V, Esser KH, Koch J, Chichkov B, Lenarz T, Paasche G. Nanostructuring of cochlear implant electrode contacts induces delayed impedance increase in vivo. Phys. Status Solidi A. 2015 Feb. 3;6; 1210-1215
2014
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Miller F, Burghard A, Salcher R, Scheper V, Leibold W, Lenarz T, Paasche G. Treatment of middle ear ventilation disorders: sheep as animal model for stenting the human eustachian tube - a cadaver study. PLoS One. 2014 Nov 24;9(11):e113906. doi: 10.1371/journal.pone.0113906. eCollection 2014.
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Hütten M, Dhanasingh A, Hessler R, Stöver T, Esser KH, Möller M, Lenarz T, Jolly C, Groll J, Scheper V. In vitro and in vivo evaluation of a hydrogel reservoir as a continuous drug delivery system for inner ear treatment. PLoS One. 2014 Aug 8;9(8):e104564. doi: 10.1371/journal.pone.0104564. eCollection 2014.
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Kranz K, Warnecke A, Lenarz T, Durisin M, Scheper V. Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro. PLoS One. 2014 Mar 18;9(3):e92157. doi: 10.1371/journal.pone.0092157. eCollection 2014
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Ceschi P, Bohl A, Sternberg K, Neumeister A, Senz V, Schmitz KP, Kietzmann M, Scheper V, Lenarz T, Stöver T, Paasche G. Biodegradable polymeric coatings on cochlear implant surfaces and their influence on spiral ganglion cell survival. J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1255-67. doi: 10.1002/jbm.b.33110. Epub 2014 Jan 17
2013
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Rode T, Hartmann T, Hubka P, Scheper V, Lenarz M, Lenarz T, Kral A, Lim HH. Neural representation in the auditory midbrain of the envelope of vocalizations based on a peripheral ear model. Front Neural Circuits. 2013 Oct 21;7:166. doi: 10.3389/fncir.2013.00166. eCollection 2013.
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Wrzeszcz A, Reuter G, Nolte I, Lenarz T, Scheper V. Spiral ganglion neuron quantification in the guinea pig cochlea using Confocal Laser Scanning Microscopy compared to embedding methods. Hear Res. 2013 Dec;306:145-55. doi:10.1016/j.heares.2013.08.002. Epub 2013 Aug 20.
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Hütten M, Ehrhart F, Zimmermann H, Reich U, Esser KH, Lenarz T, Scheper V. UHV-alginate as matrix for neurotrophic factor producing cells--a novel biomaterial for cochlear implant optimization to preserve inner ear neurons from degeneration. Otol Neurotol. 2013 Aug;34(6):1127-33. doi: 10.1097/MAO.0b013e3182804949. Erratum in: Otol Neurotol. 2013 Dec;34(9):1751
Before 2013
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Meyer H, Stöver T, Fouchet F, Bastiat G, Saulnier P, Bäumer W, Lenarz T, Scheper V. Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. Int J Nanomedicine. 2012;7:2449-64. doi: 10.2147/IJN.S29712. Epub 2012 May 15.
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Kontorinis G, Scheper V, Wissel K, Stöver T, Lenarz T, Paasche G. In vitro modifications of the scala tympani environment and the cochlear implant array surface. Laryngoscope. 2012 Sep;122(9):2057-63. doi: 10.1002/lary.23408. Epub 2012 May 30.
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Calixto R, Lenarz M, Neuheiser A, Scheper V, Lenarz T, Lim HH. Coactivation of different neurons within an isofrequency lamina of the inferior colliculus elicits enhanced auditory cortical activation. J Neurophysiol. 2012 Aug;108(4):1199-210. doi: 10.1152/jn.00111.2012. Epub 2012 May 23.
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Warnecke A, Sasse S, Wenzel GI, Hoffmann A, Gross G, Paasche G, Scheper V, Reich U, Esser KH, Lenarz T, Stöver T, Wissel K. Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo. Hear Res. 2012 Jul;289(1-2):86-97. doi: 10.1016/j.heares.2012.04.007. Epub 2012 Apr 28.
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Warnecke A, Scheper V, Buhr I, Wenzel GI, Wissel K, Paasche G, Berkingali N, Jørgensen JR, Lenarz T, Stöver T. Artemin improves survival of spiral ganglion neurons in vivo and in vitro. Neuroreport. 2010 May 12;21(7):517-21. doi:10.1097/WNR.0b013e328339045b.
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Scheper V, Wolf M, Scholl M, Kadlecova Z, Perrier T, Klok HA, Saulnier P, Lenarz T, Stöver T. Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules. Nanomedicine (Lond). 2009 Aug;4(6):623-35. doi: 10.2217/nnm.09.41.
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Scheper V, Paasche G, Miller JM, Warnecke A, Berkingali N, Lenarz T, Stöver T. Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs. J Neurosci Res. 2009 May 1;87(6):1389-99. doi: 10.1002/jnr.21964.
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Stöver T, Scheper V, Diensthuber M, Lenarz T, Wefstaedt P. In vitro neurite outgrowth induced by BDNF and GDNF in combination with dexamethasone on cultured spiral ganglion cells. Laryngorhinootologie. 2007 May;86(5):352-7. Epub 2006 Dec 12. German.
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Wefstaedt P, Scheper V, Rieger H, Lenarz T, Stöver T. Neurotrophic factors of the GDNF family and their receptors are detectable in spiral ganglion cells of normal hearing as well as of deafened rats. Laryngorhinootologie. 2006 Nov;85(11):802-8. Epub 2006 Apr 10. German.
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Wefstaedt P, Scheper V, Lenarz T, Stöver T. Brain-derived neurotrophic factor/glial cell line-derived neurotrophic factor survival effects on auditory neurons are not limited by dexamethasone. Neuroreport. 2005 Dec 19;16(18):2011-4.