Publications - VIANNA

2024

Nassauer L, Schott JW, Harre J, Warnecke A, Morgan M, Galla M, Schambach A.The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells. J Mol Med (Berl). 2024 Aug 7. doi: 10.1007/s00109-024-02472-2. Online ahead of print.
Giesemann A, Schöner-Heinisch A, Götz F, Steinemann D, Lesinski-Schiedat A, Warnecke A, Lanfermann H, Hartmann H, Döring K.Hamartomas of the Tuber Cinereum Associated with X-Linked Deafness Show Signs of Pubertas Tarda Instead of Pubertas Praecox and No Gelastic Seizures-Long-Term Follow-Up of 12 Years. Neuropediatrics. 2024 Jul 31. doi: 10.1055/s-0044-1788730. Online ahead of print.
Di Stadio A, Ralli M, Kaski D, Koohi N, Gioacchini FM, Kysar JW, Lalwani AK, Warnecke A, Bernitsas E. Exploring Inner Ear and Brain Connectivity through Perilymph Sampling for Early Detection of Neurological Diseases: A Provocative Proposal. Brain Sci. 2024 Jun 20;14(6):621. doi: 10.3390/brainsci14060621.
Guan C, Shaikh M, Warnecke A, Vona B, Albert JT. A burden shared: The evolutionary case for studying human deafness in Drosophila. Hear Res. 2024 Sep 1;450:109047. doi: 10.1016/j.heares.2024.109047. Epub 2024 Jun 15.
Tsilivigkos C, Vitkos EN, Ferekidis E, Warnecke A. Can Multifrequency Tympanometry Be Used in the Diagnosis of Meniere's Disease? A Systematic Review and Meta-Analysis. J Clin Med. 2024 Mar 4;13(5):1476. doi: 10.3390/jcm13051476.
Nassauer L, Staecker H, Huang P, Renslo B, Goblet M, Harre J, Warnecke A, Schott JW, Morgan M, Galla M, Schambach A. Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL. Mol Ther Nucleic Acids. 2024 Feb 19;35(1):102157. doi: 10.1016/j.omtn.2024.102157. eCollection 2024 Mar 12.
Döring K, Ivanyi P, Lanfermann H, Warnecke A, Giesemann A. Langerhans cell histiocytosis involving the temporal bone with destruction and subsequent reossification of the bony labyrinth boundaries. Rofo. 2024 Feb 19. doi: 10.1055/a-2254-5536. Online ahead of print.
Räth M, Schurzig D, Timm ME, Lenarz T, Warnecke A. Correlation of Scalar Cochlear Volume and Hearing Preservation in Cochlear Implant Recipients with Residual Hearing. Otol Neurotol. 2024 Mar 1;45(3):256-265. doi: 10.1097/MAO.0000000000004122. Epub 2024 Jan 24.
Winter G, Löffelmann T, Chaya S, Kaiser H, Prenzler NK, Warnecke A, Wetzke M, Derlin T, Renz D, Stueber T, Länger F, Schütz K, Schwerk N. Relapsing Polychondritis with Tracheobronchial Involvement: A Detailed Description of Two Pediatric Cases and Review of the Literature. Klin Padiatr. 2024 Feb;236(2):97-105. doi: 10.1055/a-2230-1521. Epub 2024 Jan 15.

2023

Pan X, Huang P, Ali SS, Renslo B, Hutchinson TE, Erwin N, Greenberg Z, Ding Z, Li Y, Warnecke A, Fernandez NE, Staecker H, He M. CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss. bioRxiv [Preprint]. 2023 Dec 15:2023.09.14.557853. doi: 10.1101/2023.09.14.557853.
Schott JW, Huang P, Morgan M, Nelson-Brantley J, Koehler A, Renslo B, Büning H, Warnecke A, Schambach A, Staecker H. Third-generation lentiviral gene therapy rescues function in a mouse model of Usher 1B. Mol Ther. 2023 Dec 6;31(12):3502-3519. doi: 10.1016/j.ymthe.2023.10.018. Epub 2023 Oct 31.
Di Stadio A, De Luca P, Koohi N, Kaski D, Ralli M, Giesemann A, Hartung HP, Altieri M, Messineo D, Warnecke A, Frohman T, Frohman EM. Neuroinflammatory disorders of the brain and inner ear: a systematic review of auditory function in patients with migraine, multiple sclerosis, and neurodegeneration to support the idea of an innovative 'window of discovery'. Front Neurol. 2023 Aug 10;14:1204132. doi: 10.3389/fneur.2023.1204132. eCollection 2023.
Prenzler NK, Salcher R, Lenarz T, Gaertner L, Lesinski-Schiedat A, Warnecke A. Deep intracochlear injection of triamcinolone-acetonide with an inner ear catheter in patients with residual hearing. Front Neurosci. 2023 Jul 26;17:1202429. doi: 10.3389/fnins.2023.1202429. eCollection 2023.
Wang D, Wang H, Fan L, Ludwig T, Wegner A, Stahl F, Harre J, Warnecke A, Zeilinger C. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6(7):997-1005. doi: 10.1021/acsptsci.3c00056. eCollection 2023 Jul
Tropitzsch A, Schade-Mann T, Gamerdinger P, Dofek S, Schulte B, Schulze M, Fehr S, Biskup S, Haack TB, Stöbe P, Heyd A, Harre J, Lesinski-Schiedat A, Büchner A, Lenarz T, Warnecke A, Müller M, Vona B, Dahlhoff E, Löwenheim H, Holderried M. Variability in Cochlear Implantation Outcomes in a Large German Cohort With a Genetic Etiology of Hearing Loss. Ear Hear. 2023 Nov-Dec 01;44(6):1464-1484. doi: 10.1097/AUD.0000000000001386. Epub 2023 Jul 13.
Nowak J, Bentele M, Kutle I, Zimmermann K, Lühmann JL, Steinemann D, Kloess S, Koehl U, Roßberg W, Ahmed A, Schaudien D, Neubert L, Kamp JC, Kuehnel MP, Warnecke A, Schambach A, Morgan M. CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC). Cancers (Basel). 2023 Jun 13;15(12):3169. doi: 10.3390/cancers15123169.
Jonard L, Brotto D, Moreno-Pelayo MA, Del Castillo I, Kremer H, Pennings R, Caria H, Fialho G, Boudewyns A, Van Camp G, Ołdak M, Oziębło D, Deggouj N, De Siati RD, Gasparini P, Girotto G, Verstreken M, Dossena S, Roesch S, Battelino S, Trebušak Podkrajšek K, Warnecke A, Lenarz T, Lesinski-Schiedat A, Mondain M, Roux AF, Denoyelle F, Loundon N, Serey Gaut M, Trevisi P, Rubinato E, Martini A, Marlin S. Genetic Evaluation of Prelingual Hearing Impairment: Recommendations of an European Network for Genetic Hearing Impairment. Audiol Res. 2023 May 10;13(3):341-346. doi: 10.3390/audiolres13030029.
Warnecke A, Staecker H, Rohde E, Gimona M, Giesemann A, Szczepek AJ, Di Stadio A, Hochmair I, Lenarz T. Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations. J Clin Med. 2022 Dec 15;11(24):7455. doi: 10.3390/jcm11247455.
Roßberg W, Dagistani A, Mitovska D, Krüger C, Warnecke A, Lenarz T, Durisin M. Zungengrundhyperplasie nach Tonsillektomie und Korrelation mit dem BMI [Hypertrophy of lingual tonsil following tonsillectomy and correlation with BMI]. Laryngorhinootologie. 2023 May;102(5):357-363. German. doi: 10.1055/a-1887-6352. Epub 2022 Dec 21.
Eggers H, Häbel L, Ganser A, Grünwald V, Merten R, Warnecke A, Durisin M, Ivanyi P. Anti-EGFR-Based Therapy in Recurrent or Metastatic HNSCC - What Difference Does it Make? Cancer Invest. 2023 Jan;41(1):93-100. doi: 10.1080/07357907.2022.2134414. Epub 2022 Oct 25.
Warnecke A, Staecker H, Rohde E, Gimona M, Giesemann A, Szczepek AJ, Di Stadio A, Hochmair I, Lenarz T. Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations. J Clin Med. 2022 Dec 15;11(24):7455. doi: 10.3390/jcm11247455.
Harre J, Heinkele L, Steffens M, Warnecke A, Lenarz T, Just I, Rohrbeck A. Corrigendum: Potentiation of brain-derived neurotrophic factor-induced protection of spiral ganglion neurons by C3 exoenzyme/Rho inhibitor. Front Cell Neurosci. 2022 Nov 3;16:1078962. doi: 10.3389/fncel.2022.1078962. Erratum for: Front Cell Neurosci. 2021 Mar 11;15:602897.

2022

Hoffmann AC, Warnecke A, Timm ME, Kludt E, Prenzler NK, Gärtner L, Lenarz T, Salcher RB. Cochlear Implantation in Obliterated Cochlea: A Retrospective Analysis and Comparison between the IES Stiff Custom-Made Device and the Split-Array and Regular Electrodes. J Clin Med. 2022 Oct;11(20):6090. Published online 2022 Oct 16. doi: 10.3390/jcm11206090 *shared authorship
Fan L, Kishore A, Jansen-Olliges L, Wang D, Stahl F, Psathaki OE, Harre J, Warnecke A, Weder J, Preller M, Zeilinger C. Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta. ACS Omega. 2022 Aug 9;7(33):28932-28945. doi: 10.1021/acsomega.2c02331.
Avallone E, Schmitt H, Lilli G, Warnecke A, Lesinski-Schiedat A, Lenarz T, Willenborg K. A potential serological biomarker for inner ear pathologies: OTOLIN-1. Acta Otorhinolaryngol Ital. 2022 Aug;42(4):364-371. doi: 10.14639/0392-100X-N2074.
Fan L, Warnecke A, Weder J, Preller M, Zeilinger C. Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site. Int J Mol Sci. 2022 Jun 28;23(13):7150. doi: 10.3390/ijms23137150. eCollection 2022.
St Peter M, Brough DE, Lawrence A, Nelson-Brantley J, Huang P, Harre J, Warnecke A, Staecker H. Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications. Front Bioeng Biotechnol. 2022 Jun 3;10:892969. doi: 10.3389/fbioe.2022.892969.
Van Dieken A, Staecker H, Schmitt H, Harre J, Pich A, Roßberg W, Lenarz T, Durisin M, Warnecke A. Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas Front. Cell Dev. Biol., 28 April 2022. doi: 10.3389/fcell.2022.847157.
Yilmaz-Bayraktar S, Foremny K, Kreienmeyer M, Warnecke A, Doll T. Medical- Grade Silicone Rubber-Hydrogel-Composites for Modiolar Hugging Cochlear Implants. Polymers (Basel). 2022 Apr 26;14(9):1766. doi: 10.3390/polym14091766.
Pietsch M, Schurzig D, Salcher R, Warnecke A, Erfurt P, Lenarz T, Kral A. Variations in microanatomy of the human modiolus require individualized cochlear implantation. Sci Rep. 2022 Mar 23;12(1):5047. doi: 10.1038/s41598-022-08731-x.
Durisin M, Krüger C, Pich A, Warnecke A, Steffens M, Zeilinger C, Lenarz T, Prenzler N, Schmitt H. Proteome profile of patients with excellent and poor speech intelligibility after cochlear implantation: Can perilymph proteins predict performance? PLoS One. 2022 Mar 3;17(3):e0263765. doi: 10.1371/journal.pone.0263765. eCollection 2022.
Wille I, Harre J, Oehmichen S, Lindemann M, Menzel H, Ehlert N, Lenarz T, Warnecke A, Behrens P. Development of Neuronal Guidance Fibers for Stimulating Electrodes: Basic Construction and Delivery of a Growth Factor. Front Bioeng Biotechnol. 2022 Jan 24;10:776890. doi: 10.3389/fbioe.2022.776890. eCollection 2022
Peter MS, Warnecke A, Staecker H. A Window of Opportunity: Perilymph Sampling from the Round Window Membrane Can Advance Inner Ear Diagnostics and Therapeutics. Journal of Clinical Medicine. 2022; 11(2):316.
Warnecke A, Kaiser O, Lenarz T. Editorial: 2nd International Symposium on Inner Ear Therapeutics. Hear Res. 2022 Jan;413:108370. doi: 10.1016/j.heares.2021.108370. Epub 2021 Oct 7. PMID: 34674898
Schulze J, Staecker H, Wedekind D, Lenarz T, Warnecke A. Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application. Hear Res. 2022 Jan;413:108098. doi: 10.1016/j.heares.2020.108098. Epub 2020 Oct 21.

2021

Grosser D, Willenborg K, Dellani P, Avallone E, Götz F, Bothing D, Warnecke A, Lanfermann H, Lenarz T, Giesemann A. Vestibular Aqueduct Size Correlates With the Degree of Cochlear Hydrops in Patients With and Without Meniere's Disease. Otol Neurotol. 2021 Dec 1;42(10):e1532-e1536. doi: 10.1097/MAO.0000000000003300.
Warnecke A, Harre J, Shew M, Mellott AJ, Majewski I, Durisin M, Staecker H. Successful Treatment of Noise-Induced Hearing Loss by Mesenchymal Stromal Cells: An RNAseq Analysis of Protective/Repair Pathways. Front Cell Neurosci. 2021 Nov 23;15:656930. doi: 10.3389/fncel.2021.656930. eCollection 2021.
Wichova H, Shew M, Nelson-Brantley J, Warnecke A, Prentiss S, Staecker H. MicroRNA Profiling in the Perilymph of Cochlear Implant Patients: Identifying Markers that Correlate to Audiological Outcomes. J Am Acad Audiol. 2021 Nov;32(10):627-635. doi: 10.1055/s-0041-1742234. Epub 2022 May 24. PMID: 35609590.
Zhuang P, Phung S, Warnecke A, Arambula A, St Peter M, He M, Staecker H. Isolation of sensory hair cell specific exosomes in human perilymph. Neurosci Lett. 2021 Nov 1;764:136282. Neurosci Lett. 2021 Nov 1;764:136282. doi: 10.1016/j.neulet.2021.136282. Epub 2021 Oct 4.
Shew M, Wichova H, Warnecke A, Lenarz T, Staecker H. Evaluating Neurotrophin Signaling Using MicroRNA Perilymph Profiling in Cochlear Implant Patients With and Without Residual Hearing. Otol Neurotol. 2021 May 10. doi: 10.1097/MAO.0000000000003182.
Schmitt H, Pich A, Prenzler NK, Lenarz T, Harre J, Staecker H, Dursisin M, Lenarz T, Warnecke A. Personalized proteomics for precision diagnostics in hearing loss: Disease-specific analysis of human perilymph by mass spectrometry. ACS Omega. 2021 Aug.; 13;6(33):21241-21254. doi: 10/1021/acsomega.1c01136
McLean WJ, Hinton AS, Herby JTJ, Salt AN, Hartsock JJ, Wilson S, Lucchino DL, Lenarz T, Warnecke A, Prenzler N, Schmitt H, King S, Jackson LE, Rosenbloom J, Atiee G, Bear M, Runge CL, Gifford RH, Rauch SD, Lee DJ, Langer R, Karp JM, Loose C, LeBel C. Improved speech intelligibility in subjects with stable sensorineural hearing loss following intratympanic dosing of FX-322 in a Phase 1b study. Otol Neurotol. 2021 Aug 1;42(7):e849-e857. doi: 10.1097/MAO.0000000000003120.
Shew M, Wichova H, St Peter M, Warnecke A, Staecker H. Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière’s Disease. Front. Neurol. 2021;12:646928. doi: 10.3389/fneur.2021.646928
Warnecke A., Prenzler N., Harre J., Köhl U., Gärtner L., Lenarz T., Laner-Plamberger S., Wietzorrek G., Staecker H., Lassacher T., Hollerweger J., Gimona M., Rohde E. First-in-human intracochlear application of 1 extracellular vesicle-enriched secretome from umbilical cord mesenchymal stromal cells in a patient with Menière’s disease during cochlear implantation. J Extracell Vesicles. 2021 Jun 04; 10:e12094. doi: 10.1002/jev2.12094.
Heeger P, Harre J, Warnecke A, Mueller D, Kalies S, Heisterkamp A. Probing interneuronal cell communication via optogenetic stimulation. Translational Biophotonics. 2021;3(3):e202100002. doi: 10.1002/tbio.202100002
Warnecke A, Giesemann A. Embryology, malformations and rare diseases of the cochlea. Laryngorhinootologie. 2021 Apr.; 100(S01):S1-S43. doi: 10/1055/a-1349-3824
Harre J, Heinkele L, Steffens M, Warnecke A, Lenarz T, Just I, Rohrbeck A. Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor. Front Cell Neurosci. 2021 Mar 11;15:602897. doi: 10.3389/fncel.2021.602897. eCollection 2021. Erratum in: Front Cell Neurosci. 2022 Nov 03;16:1078962.
Salcher R, Boruchov A, Timm M, Steffens M, Giesemann A, Lenarz T, Warnecke A. On the Intracochlear Location of Straight Electrode Arrays After Cochlear Implantation: How Lateral Are Lateral Wall Electrodes? Otol Neurotol. 2021 Feb 1;42(2):242-250. doi: 10.1097/MAO.0000000000002880. PMID: 33026778.
Shew M, Wichova H, Bur A, Koestler DC, St Peter M, Warnecke A, Staecker H. MicroRNA Profiling as a Methodology to Diagnose Ménière's Disease: Potential Application of Machine Learning. Otolaryngol Head Neck Surg. 2021 Feb;164(2):399-406. doi: 10.1177/0194599820940649. Epub 2020 Jul 14. PMID: 32663060.

2020

Espersen J, Weber U, Römer-Franz A, Lenarz T, Stolle SRO, Warnecke A. Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis. PLoS One. 2020 Dec 17;15(12):e0243732. doi: 10.1371/journal.pone.0243732. PMID: 33332460; PMCID: PMC7746182.
Warnecke A, Harre J, Staecker H, Prenzler N, Strunk D, Couillard-Despres S, Romanelli P, Hollerweger J, Lassacher T, Auer D, Pachler K, Wietzorrek G, Köhl U, Lenarz T, Schallmoser K, Laner-Plamberger S, Falk CS, Rohde E, Gimona M. Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo. Clin Transl Med. 2020 Dec;10(8):e262. doi: 10.1002/ctm2.262.
Knipper M, van Dijk P, Schulze H, Mazurek B, Krauss P, Scheper V, Warnecke A, Schlee W, Schwabe K, Singer W, Braun C, Delano PH, Fallgatter AJ, Ehlis AC, Searchfield GD, Munk MHJ, Baguley DM, Rüttiger L. The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants. J Neurosci. 2020 Sep 16;40(38):7190-7202. doi: 10.1523/JNEUROSCI.1314-19.2020.
Prenzler NK, Weller T, Steffens M, Lesinski-Schiedat A, Büchner A, Lenarz T, Warnecke A. Impedance Values Do Not Correlate With Speech Understanding in Cochlear Implant Recipients. Otol Neurotol. 2020 Jul 14. doi: 10.1097/MAO.0000000000002743.
Peter MN, Paasche G, Reich U , Lenarz T , Warnecke A. Differential Effects of Low- And High-Dose Dexamethasone on Electrically Induced Damage of the Cultured Organ of Corti. Neurotox. 03 June 2020. doi: 10.1007/s12640-020-00228-7.
El-Saied S, Schmitt H, Durisin M, Joshua BZ, Abu Tailakh M, Prenzler N, Lenarz T, Kaplan DM, Lewis EC, Warnecke A. Endogenous α1-antitrypsin levels in the perilymphatic fluid correlates with severity of hearing loss. Clin Otolaryngol. 2020 Apr 4. doi: 10.1111/coa.13541.
Heilen S, Lang CP, Warnecke A, Lenarz T, Durisin M. Exploratory tympanotomy in sudden sensorineural hearing loss for the identification of a perilymphatic fistula - retrospective analysis and review of the literature. J Laryngol Otol. 2020 Jun;134(6):501-508. doi: 10.1017/S0022215120000948.
Prenzler NK, Salcher R, Lenarz T, Gaertner L, Warnecke A. Dose-Dependent Transient Decrease of Impedances by Deep Intracochlear Injection of Triamcinolone With a Cochlear Catheter Prior to Cochlear Implantation-1 Year Data. Front Neurol. 2020 Apr 15;11:258. doi:10.3389/fneur.2020.00258. eCollection 2020.
Majdani E, Majdani O, Steffens M, Warnecke A, Lesinski-Schiedat A, Lenarz T, Götz F. Dimensions of artefacts caused by cochlear and auditory brainstem implants in magnetic resonance imaging. Cochlear Implants Int. 2020 Mar;21(2):67-74. doi: 10.1080/14670100.2019.1668617.
Claußen M, Schulze J, Nothwang HG. Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice. Hear Res 2020;391:107950. doi: 10.1016/j.heares.2020.107950.
Zelener F, Majdani O, Roemer A, Lexow GJ, Giesemann A, Lenarz T, Warnecke A. Relations Between Scalar Shift and Insertion Depth in Human Cochlear Implantation. Otol Neurotol. 2020 Feb;41(2):178-185. doi: 10.1097/MAO.0000000000002460.

2019

Weininger O, Warnecke A, Lesinski-Schiedat A, Lenarz T, Stolle S. Computational analysis based on audioprofiles: A new possibility for patient stratification in office-based otology. Audiol Res. 2019 Nov 5;9(2):230. doi: 10.4081/audiores.2019.230. eCollection 2019 Sep 2.
Wang H, Stahl F, Scheper T, Steffens M, Warnecke A, Zeilinger C. Microarray-Based Screening System Identifies Temperature-Controlled Activity of Connexin 26 That Is Distorted by Mutations. Scientific Reports 9, no. 1 (December 19, 2019): 13543. doi:10.1038/s41598-019-49423-3.
Schulze J, Nolte L, Lyutenski S, Tinne N, Heinemann D, Ripken T, Willaredt MA, Nothwang HG, Lenarz T, Warnecke A. Scanning laser optical tomography in a neuropathic mouse model : Visualization of structural changes. HNO. 2019 Aug;67(8):590-599. doi: 10.1007/s00106-019-0652-4.
Schulze J, Nolte L, Lyutenski S, Tinne N, Heinemann D, Ripken T, Willaredt MA, Nothwang HG, Lenarz T, Warnecke A. Scannende laseroptische Tomographie in einem neuropathischen Mausmodell. HNO. 2019 Aug;67(8):590-599. doi: 10.1007/s00106-019-0652-4.
Warnecke A, Prenzler NK, Schmitt H, Daemen K, Keil J, Dursin M, Lenarz T, Falk CS. Defining the Inflammatory Microenvironment in the Human Cochlea by Perilymph Analysis: Toward Liquid Biopsy of the Cochlea. Front Neurol. 2019 Jun 25;10:665. doi: 10.3389/fneur.2019.00665.
Schilder AGM, Su MP, Blackshaw H, Lustig L, Staecker H, Lenarz T, Safieddine S, Gomes-Santos CS, Holme R, Warnecke A. Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders. Otol Neurotol. 2019 Jun;40(5):559-570. doi: 10.1097/MAO.0000000000002194.
de Vries I, Schmitt H, Lenarz T, Prenzler N, Alvi S, Staecker H, Durisin M, Warnecke A. Detection of BDNF-Related Proteins in Human Perilymph in Patients With Hearing Loss. Front Neurosci. 2019 Mar 26;13:214. doi: 10.3389/fnins.2019.00214.
Peter MN, Paasche G, Reich U, Lenarz T, Warnecke A. Reactions in the organ of Corti to electrical stimulation : StED technology for detecting changes. HNO. 2019 Apr;67(4):251-257. doi: 10.1007/s00106-019-0641-7. German.
Peter MN, Warnecke A, Reich U, Olze H, Szczepek AJ, Lenarz T, Paasche G. Influence of In Vitro Electrical Stimulation on Survival of Spiral Ganglion Neurons. Neurotox Res. 2019 Jul;36(1):204-216. doi: 10.1007/s12640-019-00017-x.

2018

Schulze J, Sasse S, Prenzler N, Staecker H, Mellott AJ, Roemer A, Durisin M, Lenarz T, Warnecke A. Microenvironmental support for cell delivery to the inner ear. Hear Res. 2018 Oct;368:109-122. doi: 10.1016/j.heares.2018.06.015.
Shew M, Warnecke A, Lenarz T, Schmitt H, Gunewardena S, Staecker H. Feasibility of microRNA profiling in human inner ear perilymph. Neuroreport. 2018 Aug 1;29(11):894-901. doi: 10.1097/WNR.0000000000001049.
Schilder AGM, Blackshaw H, Lenarz T, Warnecke A, Lustig LR, Staecker H. Biological Therapies of the Inner Ear: What Otologists Need to Consider. Otol Neurotol. 2018 Feb;39(2):135-137. doi: 10.1097/MAO.0000000000001689.
Prenzler NK, Salcher R, Timm M, Gaertner L, Lenarz T, Warnecke A. Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study. Drug Deliv Transl Res. 2018 May 14. doi: 10.1007/s13346-018-0539-z.
Yue Q, Stahl F, Plettenburg O, Kirschning A, Warnecke A, Zeilinger C. Non-competitive effect of gambogic acid displaces fluorescence labelled ATP but requires ATP for binding to Hsp90/HtpG. Biochemistry. 2018 Apr 17. doi:10.1021/acs.biochem.8b00155.
Schmidt N, Schulze J, Warwas DP, Ehlert N, Lenarz T, Warnecke A, Behrens P. Long-term delivery of brain-derived neurotrophic factor (BDNF) from nanoporous silica nanoparticles improves the survival of spiral ganglion neurons in vitro. PLoS One. 2018 Mar 27;13(3). doi: e0194778.
Schmitt H, Roemer A, Zeilinger C, Salcher R, Durisin M, Staecker H, Lenarz T, Warnecke A. Heat Shock Proteins in Human Perilymph: Implications for Cochlear Implantation. Otol Neurotol. 2018 Jan;39(1):37-44.
Stolle M, Schulze J, Roemer A, Lenarz T, Durisin M, Warnecke A. Human Plasma Rich in Growth Factors Improves Survival and Neurite Outgrowth of Spiral Ganglion Neurons In Vitro. Eng Part A. 2018 Mar;24(5-6):493-501.doi: 10.1089/ten.TEA.2017.0120.

2017

Roemer A, Warnecke A, Lenarz T, Stolle SRO. Successful Treatment of Intractable Facial Osteomyelitis with Autologous PRP and Gentamicin. Clin Otorlyryngol (2017)1:1 011.
Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A. Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS One. 2017 May 23;12(5).doi: e0178182.
Trebesch S, Koch T, Warnecke A, Lenarz T, Stolle S. Objective and subjective assessment of outcomes after sinus surgery in sixty patients. Clin Otolaryngol. 2017 May 02;42(6):1400-1403. doi: 10.1111/coa.12897.
Nolte L, Tinne N, Schulze J, Heinemann D, Antonopoulos GC, Meyer H, Nothwang HG, Lenarz T, Heisterkamp A, Warnecke A, Ripken T. Scanning laser optical tomography for in toto imaging of the murine cochlea. PLOS One. 2017Apr 7. doi: e0175431.
Roemer A, Staecker H, Sasse S, Lenarz T, Warnecke A. Biologische Therapien in der Otologie. HNO. 2017 Feb 15. doi: 10.1007/s00106-016-0304-x.

2016

Roger Y, Schäck LM, Koroleva A, Noack S, Kurselis K, Krettek C, Chichkov B, Lenarz T, Warnecke A, Hoffmann A. Grid-like surface structures in thermoplastic polyurethane induce anti-inflammatory and anti-fibrotic processes in bone marrow-derived mesenchymal stem cells. Colloids Surf B Biointerfaces. 2016 Dec;148:104-115. doi: 10.1016/j.colsurfb.2016.06.024. Epub 2016 Jun 16.
Roemer A, Köhl U, Majdani O, Klöß S, Falk C, Haumann S, Lenarz T, Kral A, Warnecke A. Biohybrid cochlear implants in human neurosensory restoration. Stem Cell Res Ther. 2016 Oct 7;7(1):148. doi: 10.1186/s13287-016-0408-y
Schäck L, Budde S, Lenarz T, Krettek C, Gross G, Windhagen H, Hoffmann A, Warnecke A. Induction of neuronal-like phenotype in human mesenchymal stem cells by overexpression of Neurogenin1 and treatment with neurotrophins. Tissue Cell. 2016 Oct;48(5):524-32. doi: 10.1016/j.tice.2016.06.011. Epub 2016 Jun 27.
Hadler C, Aliuos P, Brandes G, Warnecke A, Bohlmann J, Dempwolf W, Menzel H, Lenarz T, Reuter G, Wissel K2. Polymer Coatings of Cochlear Implant Electrode Surface - An Option for Improving Electrode-Nerve-Interface by Blocking Fibroblast Overgrowth. PLoS One. 2016 Jul;11(7):e0157710. doi: 10.1371/journal.pone.0157710. eCollection 2016.
Burblies N, Schulze J, Schwarz HC, Kranz K, Motz D, Vogt C, Lenarz T, Warnecke A, Behrens P.Coatings of Different Carbon Nanotubes on Platinum Electrodes for Neuronal Devices: Preparation, Cytocompatibility and Interaction with Spiral Ganglion Cells. PLoS One. 2016 Jul;11(7):e0158571. doi: 10.1371/journal.pone.0158571. eCollection 2016.
Lamm H, Müller-Kortkamp C, Warnecke A, Pohl F, Paasche G, Lenarz T, Stolle SR. Concurrent hyperbaric oxygen therapy and intratympanic steroid application as salvage therapy after severe sudden sensorineural hearing loss. Clin Case Rep. 2016 Feb;4(3):287-93. doi: 10.1002/ccr3.510. eCollection 2016.
Aliuos P, Schulze J, Schomaker M, Reuter G, Stolle SR, Werner D, Ripken T, Lenarz T, Warnecke A.Magnetic Beads Enhance Adhesion of NIH 3T3 Fibroblasts: A Proof-of-Principle In Vitro Study for Implant-Mediated Long-Term Drug Delivery to the Inner Ear. PLoS One. 2016 Feb;11(2):e0150057. doi: 10.1371/journal.pone.0150057. eCollection 2016.
Burke WF, Warnecke A, Schöner-Heinisch A, Lesinski-Schiedat A, Maier H, Lenarz T. Prevalence and audiological profiles of GJB2 mutations in a large collective of hearing impaired patients. Hear Res. 2016 Mar;333:77-86. doi: 10.1016/j.heares.2016.01.006. Epub 2016 Jan 15.

2015

Schwieger J, Warnecke A, Lenarz T, Esser KH, Scheper V. Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination. PLoS One. 2015 Aug 11;10(8):e0133680. doi: 10.1371/journal.pone.0133680. eCollection 2015.
Helmstaedter V, Tellkamp R, Majdani O, Warnecke A, Lenarz T, Durisin M. High-frequency jet ventilation for endolaryngotracheal surgery - chart review and procedure analysis from the surgeon's and the anaesthesiologist's point of view. Clin Otolaryngol. 2015 Aug;40(4):341-8. doi: 10.1111/coa.12376.
Reich U, Warnecke A, Szczepek AJ, Mazurek B, Olze H. Establishment of an experimental system to study the influence of electrical field on cochlear structures. Neurosci Lett. 2015 Jul 10;599:38-42. doi: 10.1016/j.neulet.2015.05.027. Epub 2015 May 19.
Durisin M, Büchner A, Lesinski-Schiedat A, Bartling S, Warnecke A, Lenarz T. Cochlear implantation in children with bacterial meningitic deafness: The influence of the degree of ossification and obliteration on impedance and charge of the implant. Cochlear Implants Int. 2015 May;16(3):147-58. doi: 10.1179/1754762814Y.0000000094. Epub 2014 Aug 17.

2014

Wenzel GI, Sarnes P, Warnecke A, Stöver T, Jäger B, Lesinski-Schiedat A, Lenarz T. Non-penetrating round window electrode stimulation for tinnitus therapy followed by cochlear implantation. Eur Arch Otorhinolaryngol. 2014 Dec 6. doi: 10.1007/s00405-014-3413-8 [Epub ahead of print]
Wrzeszcz A, Steffens M, Balster S, Warnecke A, Dittrich B, Lenarz T, Reuter G. Hydrogel coated and dexamethasone releasing cochlear implants: Quantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model. J Biomed Mater Res B Appl Biomater. 2014 May 8. doi: 10.1002/jbm.b.33187. [Epub ahead of print]
Kranz K, Warnecke A, Durisin M, Lenarz T, Scheper V. Phosphodiesterase type 4 inhibitor Rolipram improves survival of spiral ganglion neurons in vitro. Accepted February 2014 in PLOSone
Kaiser O, Alious P, Wissel K, Lenarz T, Werner D, Reuter G, Kral A, Warnecke A. Dissociated neurons and glial cells derived from rat inferior colliculi after digestion with papain. PLoS One. 2013 Dec 12;8(12):e80490.
Balster S, Wenzel GI, Warnecke A, Steffens M, Rettenmaier A, Zhang K, Lenarz T, Reuter G. Optical cochlear implant: evaluation of insertion forces of optical fibres in a cochlear model and of traumata in human temporal bones. Biomed Tech (Berl). 2014 Feb 1;59(1):19-28.

2013

Kaiser O, Paasche G, Stöver T, Ernst S, Lenarz T, Kral A, Warnecke A. TGF-beta superfamily member activin A acts with BDNF and erythropoietin to improve survival of spiral ganglion neurons in vitro. Neuropharmacology. 2013 Aug 22;75C:416-425. doi: 10.1016/j.neuropharm.2013.08.008. [Epub ahead of print]
Aliuos P, Sen A, Reich U, Dempwolf W, Warnecke A, Hadler C, Lenarz T, Menzel H, Reuter G. Inhibition of fibroblast adhesion by covalently immobilized protein repellent polymer coatings studied by single cell force spectroscopy. J Biomed Mater Res A. 2013 Apr 18. doi: 10.1002/jbm.a.34686. [Epub ahead of print]
Alious P, Fadeeva E, Badar M, Winkel A, Mueller PP, Warnecke A, Chichkov B, Lenarz T, Reich U, Reuter G. Evaluation of single-cell force spectroscopy and microscopy to determine cell interactions with femtosecond-laser microstructured titanium surfaces. J Biomed Res Part A 2013;101(4):981-990.

Before 2013

Warnecke A, Sasse S, Wenzel GI, Hoffmann A, Gross G, Paasche G, Scheper V, Reich U, Esser K-H, Lenarz T, Stöver T, Wissel K. Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo. Hear Res. 2012 Jul;289(1-2):86-97.
Reich U, Fadeeva E, Warnecke A, Paasche G, Mueller P, Chichkov B, Stöver T, Lenarz T, Reuter G. Directing neuronal cell growth on implant material surfaces by microstructuring. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2012 May;100(4):940-947.
Warnecke A, Scheper V, Buhr I, Wenzel GI, Wissel K, Paasche G, Berkingali N, Jørgensen JR, Lenarz T, Stöver T. Artemin improves survival of spiral ganglion neurons in vivo and in vitro. Neuroreport. 2010 May 12;21(7):517-21.
Wenzel G, Warnecke A, Stöver T, Lenarz T. Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. Eur Arch Otorhinolaryngol. 2010 May;267(5):691-699.
Kramer F, Stöver T, Warnecke A, Diensthuber M, Lenarz T, Wissel K. BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol. 2010 May;98(1):31-39.
Warnecke A, Averbeck T, Soudah B, Wenzel GI, Lenarz T, Stöver T. Contact endoscopy for the evaluation of the pharyngeal and laryngeal mucosa. Laryngoscope. 2010 Feb;120(2):253-258.
Scheper V, Paasche G, Miller JM, Warnecke A, Berkingali N, Lenarz T, Stöver T. Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs. J Neurosci Res. 2009 May 1;87(6):1389-1399.
Warnecke A, Luessen P, Sandmann J, Ikic M, Rossa S, Gutzki FM, Stichtenoth DO, Tsikas D. Application of a stable-isotope dilution technique to study the pharmacokinetics of human (15)N-labelled S-nitrosoalbumin in the rat: Possible mechanistic and biological implications. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May;877(13):1375-1387.
Berkingali N, Warnecke A, Gomes P, Paasche G, Tack J, Lenarz T, Stöver T. Neurite outgrowth on cultured spiral ganglion neurons induced by erythropoietin. Hear Res. 2008 Sep;243(1-2):121-126.
Wissel K, Stöver T, Hofmann N-S, Chernajovsky Y, Daly G, Sasse S, Warnecke A, Lenarz T, Gross G, Hoffmann A. Fibroblast-mediated GDNF-delivery induces neuronal-like outgrowth in PC12 cells. Otol Neurotol. 2008 Jun;29(4):475-481.
Torkos A, Wissel K, Warnecke A, Lenarz T, Stöver T. Technical report: Laser microdissection and pressure catapulting is superior to conventional manual dissection for isolating pure spiral ganglion fractions from the cochlea. Hear Res. 2008 Jan;235(1-2):8-14.
Warnecke A, Wissel K, Hoffmann A, Hofmann N-S, Berkingali N, Groß G, Lenarz T, Stöver T. The biological effects of cell-delivered BDNF on cultured spiral ganglion cells Neuroreport. 2007 Oct;18(16)1683-1686.
Lesinski-Schiedat A, Illg A, Warnecke A, Heerman R, Bertram B, Lenarz T. Kochleaimplantation bei Kindern im 1. Lebensjahr. Vorläufige Ergebnisse. HNO. 2005 Jul;54(7):565-572.
Warnecke A, Averbeck T, Wurster U, Harmening M, Lenarz T, Stöver T. Diagnostic Relevance of β2-Transferrin for the Detection of Cerebrospinal Fluid Fistulas. Arch Otolaryngol, Head Neck Surg. 2004 Oct;130(10):1178-1184.
Savva A, Taylor M, Beatty CW. Management of Cerebrospinal Fluid Leaks Involving the Temporal Bone: Report on 92 Patients. Laryngoscope 2003 Jan;113(1):50-56.
Strome SE, Savva A, Brisset AE, Gostout BS, Lewis J, Clayton AC, McGovern R, Weaver AE, Persing D, Kasperbauer JL. Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin Cancer Res. 2002 Apr;8(4):1093-1100.
Khabie N, Savva A, Kasperbauer JL, McGovern R, Gostout B, Strome SE. Epstein-Barr Virus DNA is not increased in Tonsillar Carcinoma. Laryngoscope. 2001 May;111(5):811-814.
Tsikas D, Sandmann J, Lueßen P, Savva A, Rossa S, Stichtenoth DO, Frölich JC. S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat. Biochem Biophys. 2001 Apr;1546(2):422-434.
Tsikas D, Sandmann J, Savva A, Lueßen P, Böger RH, Gutzki F-M, Mayer B, Frölich JC. Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry. J Chrom B. 2000 May;742(1):143-153.