Development of an Implant-Linked Alginate Matrix for Cell-Mediated Neuronal Protection

The aim of this DFG-funded project is to develop a cell-mediated neuroprotection based on an alginate matrix. The cochlear implant electrode which is functionalized with a cell-alginate coating is used as model system.

ACEMg-Supplement Mediated Hearing Preservation in Cochlear Implant Patients Receiving Different Electrode Lengths

This is a follow-up project of the European Union funded project PROHEARING which was finalized in summer 2016. In PROHEARING we investigated the effect of an investigational medicinal product called Soundbites. The indication for a cochlear implant has expanded to patients with some residual hearing. Shorter and thinner atraumatic electrodes have been designed to preserve the residual hearing in the implanted ear. However, the insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body inside the cochlea, may lead to free radical formation and reduced blood perfusion of the cochlea which can result in a loss of residual hearing. This new project is a single center, randomized, placebo-controlled, double-blind
phase II clinical trial investigating the effect of free radial scavengers and a vasodilator on the residual hearing of 140 CI-patients.

STED-based Automated Fibrosis and Neuron Quantification in Cochlear Implanted Inner Ears

Bony tissue will be processed for clearing following modified established protocolls for soft tissue clearance. The cleared tissue will be imaged using STED and protocols for automated counting of neuronal cells as well as automated detection of fibrosis quantity will be implemented. The goal is to establish a clearing protocol with following automated tissue analysis using STED in an implanted bony structure, the inner ear.

About The VIANNA research team