Publications


2019

Journal Papers

Rau Th. S., Kreul D., Lexow J., Hügl S., Zuniga G. M., Lenarz Th., Majdani O. (2019e): Characterizing the size of the target region for atraumatic opening of the cochlea through the facial recess. Computerized Medical Imaging and Graphics. [ doi; IF: 3.298]. (epub ahead of print 30 Aug 2019)

GraficalAbstract

  • Highlights
    • image-processing software for analysing the cochlear hook region was developed
    • first measure for the size of the valid target region using 3D histological data of multiple temporal bone specimens
    • cochlea opening is safely possible within a region of ∅ 1.56 mm ± 0.10 mm
    • accuracy for hearing preservation surgery needs to be ≤ 0.3mm
    • anatomical 3D models depict the complexity of the cochlear hook region

Müller S., Kahrs L., Gaa J., Tauscher S., Kluge M., John S., Rau Th. S., Lenarz Th., Ortmaier T., Majdani O. (2019): Workflow assessment as a preclinical development tool. Int J Comput Assist Radiol Surg. 14(8):1389-1401. [ doi; IF: 2.155].

Hügl S., Scheper V., Gepp M. M., Lenarz Th., Rau Th. S., Schwieger J. (2019b): Coating stability and insertion forces of an alginate-cell-based drug delivery implant system for the inner ear. J Mech Behav Biomed Mater. 97: 90-98. [; doi; IF: 3.239].

GraficalAbstract

  • Highlights
    • Application of alginate-cell solution to a cochlea model as lubricant is possible.
    • Alginate-cell solution slightly increased insertion forces in a cochlea model.
    • Alginate-cell coating of an electrode array is possible.
    • Coating is considerable resistant to handling and insertion into a cochlea model.
    • Coated electrode arrays had a significant, 75% reduction of insertion forces.

Conference Papers

BMT 2019 - 53rd Annual Conference of the German Society for Biomedical Engineering (DGBMT within VDE), September 25-26, Frankfurt am Main, Germany
Hügl S., Aldag N., Becker A., Leanrz Th., Glasmacher B., Rau Th.S. (2019): Identification of factors influencing insertion characteristics of cochlear implant electrode carriers. Current Directions in Biomedical Engineering 5(1). [ doi].
Hügl S., Erfurt P., Lenarz Th., Majdani O., Rau Th.S. (2019): Reconstruction accuracy of an automated serial cross-sectional preparation technique for morphological human temporal bone imaging. Current Directions in Biomedical Engineering 5(1). [ doi].
Suzaly N., Keller M.Ch., Hügl S., Karsten E., Lenarz Th., Rau Th.S. (2019): Characterization of a measurement setup for the thermomechanical characterization of curved shape memory alloy actuators. Current Directions in Biomedical Engineering 5(1). [ doi].

Posters & Abstracts

Inner Ear Biology Workshop (IEB), 7-10 September , Padua, Italy
Schwieger J., Hügl S., Gepp M. M., Lenarz Th., Rau Th. S., Scheper V. (2019): Effect of alginate-cell based drug-delivery systems on the insertion forces of CI-electrodes.
XLVI. Congress of the European Society for Artificial Organs (ESAO), September 3-7, Hannover, Germany
Hügl S., Aldag N., Becker A., Lenarz T., Glasmacher B., Rau Th. S. (2019c): Toward understanding the impact of cochlear model curvature, insertion speed, and implant stiffness for the prediction of insertion forces. [ doi]
Rau Th. S., Suzaly N., Hügl S., Lenarz T. (2019d): On the characterization of thermomechanical properties of curved NiTi shape memory wires intended for cochlear implant electrode arrays. [ doi]
Conference on Implantable Auditory Prostheses (CIAP), July 14-19, Lake Tahoe, CA, US
Rau Th. S., Blum T., Kluge M., John S., Kahrs LA., Ortmaier T., Fröhlich M., Majdani O., Lenarz T. (2019c): Accuracy of drill depth control of an image-guided micro-stereotactic targeting system dedicated to cochlear implantation surgery.
Rau Th. S., Hügl S., Nullmeier M., Pawsey N., Majdani O., Lenarz T., Salcher R. (2019b): On the development of realistic artificial cochlea models.
Salcher R., Nullmeier M., Cramer J., Pawsey N., Lenarz T., Rau Th. S. (2019b): Artificial cochlea model material validation for insertion force measurement.
Scheper V., Hügl S., Hamm A., Gepp MM., Schulz A., Hubka P., Pannier C., Lenarz T., Rau Th. S., Hoffmann A., Schwieger J. (2019): BDNF overexpressing human stem cells in alginate for cochlear implant optimization.
Suzaly N., Hügl S., Rau Th. S., Lenarz T. (2019b): Designing shape memory alloy actuators tailored to the human cochlea geometry.
90th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery, Mai 30- June 1st, Berlin, Germany
Hügl S., Henke M., Kahrs LA., Ortmaier T., Lenarz T., Rau Th. S (2019): Entwicklung eines Versuchsstandes für die Insertionskraftmessung bei präziser Ausrichtung von Präparaten mittels stereooptischer Navigation. [ doi (dt.)] [ doi (engl.)].
Suzaly N., Hügl S., Majdani O., Lenarz T., Rau Th. S. (2019): Histologische Evaluierung des Elektrodenträgers eines Cochlea-Implantats mit einer für elektrische Erwärmung integrierten Formgedächtnislegierung. [ doi (dt.)] [ doi (engl.)].
Timm M., Stieghorst J., Kluge M., John S., Rau Th. S., Lenarz T. (2019): Auf dem Weg zur minimal-invasiven Cochlea Implantation: Erste Ergebnisse einer Kadaverstudie. [ doi (dt.)] [ doi (engl.)].
ARO 2019 Logo ARO 42nd Annual MidWinter Meeting, February 9-13, Baltimore, MD, USA
Rau Th. S., Nullmeier M., Cramer J., Hügl S., Pawsey N., Lenarz Th., Salcher R. (2019): A Method for Building Individualized Two-Dimensional Artificial Cochlea Models. In Proc. Association for Research in Otolaryngology (ARO) Vol 42:36.
Salcher R., Nullmeier M., Cramer J., Pawsey N., Lenarz Th., Rau Th. S.(2019): Validation of PTFE Artificial Cochlea Model for Insertion Force Measurements. In Proc. Association for Research in Otolaryngology (ARO) Vol 42:36.

Patents

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Previous publications can be found here:


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About The VIANNA research team